About the Centre (CMNS):
The Centre was emerged from the Nanomedicine and Drug Discovery Lab in 2012 at the University campus to accomplish the goal of enhancing advanced research in the area of nanomedicine and drug discovery. Further the lab was expanded as Molecular and Nanomedicine Research Unit in 2014. The leading area of research includes Neuroscience, Neurodegenerative disorders, Infectious Disease Biology, Nutritional Physiology, Cardiovascular Biology, Cancer Biology, Organic Chemistry, Regeneration and Stem Cell Biology. In recognition of the research progress and academic activities the Molecular and Nanomedicine Research Unit has been elevated as Centre for Molecular and Nanomedical Sciences from 2019 for further research developments. In addition to research, the Centre also conducts training programs, workshops and conferences. The Centre is undertaking research and development projects from various agencies and research organizations in India and abroad.
Mission:
To facilitate advanced research in various fields of Science & Technology at Molecular and Nanomedical leading to the development of innovative products for societal benefits.
Vision:
To establish technologies for developing high throughput screening of small drug molecules, 3D organoids, translational research in the field of Molecular and Nanomedical Sciences through Research, Awareness and Consultancy.
Research activities:
Research activities of Centre for Molecular and Nanomedical Sciences:
Current research :
- Cancer Biology Lab: Studying the molecular mechanism of angiogenesis development in breast cancer using Rat and mouse breast cancer models and also discovering novel drugs from marine sponge associated symbionts.
- Neuroscience Lab: Studying the role of the phytochemical - ar-turmerone in neural stem cell regeneration and targeting Parkinson's disease.
- Synthetic Biology Lab: Targeting microbial therapeutic enzymes and extremozymes (streptokinase (SK), tissue plasminogen activator (tPA), urokinase (UK) and nattokinase, Lipases and proteases, using latest synthetic biology techniques.
- Regeneration and Stem cell Biology Lab: Developing serum free alternative for Fetal Bovine serum for animal cell culture using earthworm coelomic fluid.
- Providing scientific molecular evidences for traditional medicines practised in southern India.
Future research directions:
- Cancer Biology Lab: Finding new therapies to reduce the side effects caused by conventional cancer therapies and exploring their molecular mechanisms using different cancer model systems.
- Regeneration and Stem cell Biology Lab: To develop organoid model for understanding the molecular mechanism of regeneration for testing preclinical drug candidates.
- Ex-vivo organ culture, regeneration augmentation, stem cells regulation, apoptotic induced compensatory proliferation, photobiology and molecular docking studies.
- Neuroscience Lab: Exploring neural stem cell-based therapy and developing disease models, particularly cerebral organoids for neurodegenerative disorders.
- Synthetic Biology Lab: Development the plant and Microbial protein based therapeutic Peptides and Peptidomimetics for Cardiovascular Diseases.
Faculty:
1. Dr. A. Dayanandan Professor - Research MSc., PhD.,
2. Dr. A. Madan Kumar Assistant Professor - Research MSc., PhD.,
3. Dr. S. Johnson Retnaraj Samuel Associate Professor - Research MSc., PhD.,
4. Dr. S. Jackson Durairaj Associate Professor - Research MSc., PhD.,
5. Dr. M. Rajasekar Assistant Professor - Research MSc., PhD.,
6. Dr. Y, Beryl Vedha Assistant Professor - Research MSc., M.Phil., PhD.,
Scientific Assistant:
1) Mr. Nandhagopal S
2) Mr. Carlton Ranjith W.A
3) Mr. Saravanakumar V
Research Fellow:
- Ms. Dhanalakshmi Research Fellow M.Sc,
- Dr. Arjun Pitchai CSIR - SRF M.Sc. PhD
- Dr. S. N. Nagabhishek ICMR-Senior Research Fellow MSc, PhD
- Dr. K. Gayathri DBT – SRF MSc, PhD
- Ms.S. Chinmye Sri Amulya JRF MSc
- Mr. CV. Niranjan Junior Research Fellow M.Sc, M.Phil.,
- Mrs. G. Mijithra Junior Research Fellow M.Sc, M.Phil.,
- Mr. V. Saravanakumar Junior Research Fellow M.Sc,
- Mr. S. Ravichandran Junior Research Fellow M.Sc,
- Ms. Melinda Grace Junior Research Fellow M.Sc,
- Mrs. Janice .R Junior Research Fellow M.Sc,
- Ms. Catherine Stephan Junior Research Fellow M.Sc,
- Mr. S.C Karthikeyan DHR - Young Scientist M.Sc., M.Phil
- Mr. R. Kamarajan Senior Research Fellow M.Tech
- Mr. Jenif Leo Anandharaj Project Associate M.Sc.,
- Ms. Sushmitha Junior Research Fellow M.Sc,
- Mr. Arulananth Junior Research Fellow M.Sc,
National – Post Doctoral Fellows:
- Dr.Sundar Raj (2018-2020) - DST
- Dr.D.Jayakar Santhosh (2017-2019) - DST
- Dr.N.Jhansi Rani (2017-2019) - DST
- Dr.M.V.Sujitha (2017-2019) - DST
- Dr.M.Rajasekar (2016-2018) - DST
- Dr.N.Nagasundaram (2016-2018) – DST
ICMR Research Associateship:
Dr. Y. Beryl Vedha (2019-2022) – ICMR
Consultancy:
Consultancy Services: (Consultancy forms attached separately)
Centre for Molecular and Nanomedical Sciences is providing following consultancy services for academics and industries;
1. RT-PCR
2. Nanopore Sequencer
3. ChemiDoc XRS+ System and Western Blotting
4. Cell Culture Facilities and Assays
5. Qubit Fluorometer
6. GC-FID
7. HPLC-PDA
8. Stereo Microscope with Fluorescence
9. Toxicity assay in Zebrafish
10. Proximate Analysis
11. Nanodrop
12. Development of Transgenic Zebrafish development
Projects:
|
SL No |
Title of Project |
Funding Agency |
Principle investigators |
Start and End Date |
Approved cost |
|
1 |
Screening and molecular characterization of Flk-1 inhibitor(s) from marine sponge symbionts and real time molecular imaging studies |
Department of Science and Technology -SERB |
Dr. A. Madan Kumar |
March-2015 to March 2018 |
25,00,000 |
|
2 |
Studies on the anticancer mechanisms of PI3K inhibitor(s) from marine sponge symbionts |
Department of Biotechnology - Govt. of India |
Dr. A. Madan Kumar |
April-2016 to Septembar-2019 |
28,67,000 |
|
3 |
Nanoparticle based Biosensor for deduction of leptospira from environmental and clinicalsamples |
Department of Science and Technology -SERB |
Dr. Jayakar Santhosh & Dr.A. Madan Kumar |
June -2016 to May-2018 |
16,20,000 |
|
4 |
Anticancer activity of crude extracts from T.violacea on human oral cancer cells |
DST- RTF-DCS |
Ms. Samkeliso & Dr.A. Madan Kumar |
June-2017 to June 2018 |
2,70,000 |
|
5. |
Sustainable livelihood development through the production of high quantity and quality meat from the backyard poultry farming using enzymes |
DST |
A.Dayanandan |
Sanctioned |
Rs.67,72,460 |
|
6. |
Preserving the tribal practice and exploring the molecular level evidence behind the use of spider web for wound healing and abscess. |
DST-SHRI |
Dr. S. Jackson Durairaj |
28-03-2022 to 27-03-2024 |
Rs 20,80,000/- |
|
7. |
Analysis of atrazine induced pathological variation associated with Alzheimers disease using a zebrafish genetic model. |
SERB-OVDF |
Dr. S. Jackson Durairaj |
11-01-2022 to 09-07-2023 |
Rs 31,20,000/- |
|
8. |
In-vitro functional organ model development for prostate cancer and its molecular characterization. |
Department of Health Research (DHR) |
Dr. S. Jackson Durairaj |
05-08-2020 to 04-08-2023 |
Rs 29,85,000/- |
|
9. |
Identification and Characterization of molecular link between lamin A and Telomere in the context of aging. |
SERB |
Dr. S. Johnson Retnaraj Samuel |
04/04/2016 to 04/07/2019 |
Rs 27,50,000/- |
|
10. |
Understanding the angiogenesis during regeneration of earthworms using foldscope. |
DBT |
Dr. S. Johnson Retnaraj Samuel |
24/05/2018 to 19/09/2019 |
Rs 8,00,000/- |
|
11. |
Molecular mechanism and multicolour imaging of ar-turmerone on neuro-regeneration. |
ICMR-RA |
Mentor: Dr. S. Johnson Retnaraj Samuel |
05/03/2019 to 04/03/2022 |
Rs 22,59,600/- |
|
12. |
Characterization of targeted small molecules for drug development, isolated from regenerating earthworms having potential wound healing and anti-bacterial properties. |
ICMR |
Dr. S. Johnson Retnaraj Samuel |
09-04-2020 to 08-04-2021 |
Rs 8,34,118/- |
|
13. |
Production, characterization and scaling-up of earthworm coelomic fluid based serum-free cell culture medium for animal cell culture |
BIRAC |
Dr. S. Johnson Retnaraj Samuel |
21-11-2020 to 20-11-2022 |
Rs 27,00,000/- |
|
14. |
Exploring an extinct heritage food “Marunthu Kulambu” used for rejuvenating the health of postpartum women and evaluating its scientific importance. |
DST |
Dr. S. Johnson Retnaraj Samuel |
23-03-2022 to 22-03-2024 |
Rs 15,69,282/- |
|
15. |
Molecular mechanistic role of ar- turmerone, a promising drug candidate for the treatment of Parkinson’s disease. |
SERB |
Dr. Y. Beryl Vedha |
2022- 2025 |
Rs 27,13,425/- |
|
16. |
Foldscope: Multicolor imaging of zebrafish brain using fluorescent sorbitol conjugates. |
DBT |
Dr. M. Rajasekar |
24/05/2018 to 19/09/2019 |
Rs 8,00,000/- |
|
17. |
Development of venom based antiepileptic peptide targeting Na channels and deciphering the mode of action in Zebrafish model. |
ICMR |
Dr. RP. Rajesh |
2020-2022 |
Rs 20,00,000/- |
Patents:
1) Dr. S. Johnson Retnaraj Samuel and Dr. S. Jackson Durairaj are the lead inventor of the Indian patent, entitled on, ‘Alternative supplement for serum in animal cell culture medium”, Application number 201941009691 – 11/12/2019.
2) Dr. M. Rajasekar is the lead Inventor in Indian patent entitled on “Synthesis of Naringenin and analogues with biocompatibility studies in zebrafish for therapeutic potential” E-101/5704/2020-CHE, 10/03/2020.
3) Madan Kumar and S.N. Nagabhishek “Monocolin x from marine sponge as an apoptosis inducing molecule” - R20194010495.
4) Madan Kumar. Active PI3K inhibitor molecule from marine sponge associated bacillus pumilus AMKI - R20194010499.
5) Dr. S.Jackson Durairaj et al., Indian patent entitled on “A deep root watering system” Application number 202241036037.
6) Dr. S. Johnson Retnaraj Samuel et al., Indian patent, entitled on, ‘Earthworm Coelomic fluid as a potential blocking agent in western blotting experiments.”, Application number 202041055479 – 21/12/2020.
Publications:
1. Prathiba Gnansekaran, Anitha roy, Nagabhishek Sirpu Natesh, Varshini Raman, Priyanka Ganapathy, A. Madan Kumar. Removal of microbial pathogens and anticancer activity of synthesized nano-thymoquinone from Nigella sativa seeds. Environmental Technology and Innovations, 24 (2021) 102068 (impact Factor – 7.758).
2. Ronald Merckx, Gopala Krishnan Durairaj, Saravanan, A. Madan Kumar, Themmila Khamrang, Hoogenboom Richard, Mani Ganeshpandian. N,N-Ru(II)-p-cymene- poly(N-vinylpyrrolidone) surface functionalized gold nanoparticles: from organorutheium complex to nanomaterial for antiproliferative activity. Dalton Transaction, (2021) 50, 8232-8242 (Impact Factor- 4.39).
3. Palanisamy Govindasamy, Nora Hamad Al-shaalan, Bhuvaneswari Kandasamy, Bharathi, Govindan, A. Madan Kumar, A. Elmarghany. An efficient and magnetically recoverable g-C3N4/ZnS/CoFe2O4 nanocomposite for sustainable photodegradation of organc dye under UV-visible light illumination. Environmental Research 201, (2021) 111429 (Impact Factor – 8.431).
4. M. Rajasekar, Review of photoresponsive and glycoside dendrimers in biomaterials and sensors applications. RSC Adv., 2022, 12, 35123-351505.
5. M. Rajasekar, InCl3-Catalyzed One-Pot Three-Component Aza-Friedel-Crafts Reactions (AFCR) of 3-Substituted Indole Derivatives and its in-Silico Mcl-1 Inhibition Studies. J. Org. Inorg. Chem, 2022, 8, 1-5.
6. M. Rajasekar, Gel Scaffolds and emerging applications in biomedicine. RSC Adv., 2022, 12, 15925-15949.
7. M. Rajasekar, Spirobifluorene derivatives and their biomaterial applications: Current Trends, J. Mol. Struct., 2022, 12, 132406.
8. M. Rajasekar, Identification and characterisation of novel wasp mastoparans and chemotactic peptides from the venom of social wasp Polistes stigma (Hymenoptera: Vespidae: Polistinae), J. Venom. Res, 2021, 11, 16-20.
9. M. Rajasekar, Adverse effect of synthesized Naringenin derivatives investigates with Zebrafish (Danio rerio) embroys. Results. Chem., 2020, 2, 100039
10. M. Rajasekar, Self-assembly of sugar-based glyco-lipids: Gelation studies of partially protected β-glucose derivatives. Mater. Sci. Eng. C., 2018, 93, 776-781
11. M. Rajasekar, In vivo safety evaluation of antibacterial silver chloride nanoparticles from Streptomyces exfoliates ICN25 in zebrafish embryos. Microb. Pathog, 2017, 112, 76-82
12. Sirpu Natesh Nagabhishek, A Madan Kumar, Sambhavi B, Anandan Balakrishnan, Suvro Chatterjee. A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling. RSC Adv., 2019, 9, 26646-26667 (Impact Factor-3.049).
13. 13.Theerthagiri J, Sunitha Salla, R A Senthil, P Nithyadharseni, A Madankumar, Prabhakarn Arunachalam, T Maiyalagan and Hyun-Seok Kim. A review on ZnO nanostructured materials: energy, environmental and biological application. Nanotechnology 30 (2019) 392001 (27pp) (Impact Factor-3.3).
14. 14.Elamathia, A. Madankumar, Werner Kaminsky, R. Prabhakarana. Synthesis, spectroscopic studies and biological evaluations of copper(I)/(II) metallates containing nitrogen heterocycles. Inorganica Chimica Acta 496 (2019) 119039 (Impact Factor- 2.450).
15. Mariadhas V A, A. Madankumar, J. Theerthagiri, Sunitha Salla, S. Prabu, Hyun-Seok Kim, Naif Abdullah Al-Dhabi, Selvaraj Arokiyaraj, Veeramuthu Duraipandiyan. Synthesis and characterization of ZnO nanoflakes anchored carbon nanoplates for antioxidant and anticancer activity in MCF7 cell lines. Materials Science & Engineering C 102, 2019. 536–540 (Impact Factor- 4.959).
16. Gayathri karanam, A Madankumar, S N Nagabhishek. Anticancer Effect of Marine Sponge‐ Associated Bacillus pumilus AMK1 Derived Dipeptide Cyclo (‐Pro‐Tyr) in Human Liver Cancer Cell Line Through Apoptosis and G2/M Phase Arrest. International Journal of Peptide Research and Therapeutics, pp 1–13, 2019 (Impact Factor- 1.219).
17. Elamathi, C. Madan Kumar A. Werner Kaminsky, R. Prabhakaran, Synthesis, spectroscopic studies and biological evaluations of copper(I)/(II) metallates containing nitrogen heterocycles. Inorganica Chimica Acta. Volume 496, 2019, 119039. ISSN 0020-1693.
18. Karanam, G., Madan Kumar A*. Sirpu Natesh, N. Combination of ZnO Nanoparticle with Marine sponge derived Dipeptide for enhances anticancer efficacy in Liver cancer cells and their toxicity evaluation in embryonic zebrafish. Current analytical chemistry. 2020.
19. SN Nagabhishek, Madan Kumar A *, Gayathri karanam. Apoptotic role of marine sponge symbiont Bacillus subtilis NMK17 through the activation of caspase-3 in human breast cancer cell line. Molecular Biology Reports, 2018. (PMID: 30414102)
20. Antony V. Samrot, B. Suvedhaa, Chamarthy Sai Sahithya, Madan Kumar A. Purification and Utilization of Gum from Terminalia Catappa L. for Synthesis of Curcumin Loaded Nanoparticle and Its In Vitro Bioactivity Studies. Journal of Cluster Science, 2018, Volume 29, Issue 6, pp 989–1002
21. Madan Kumar. A, Tamilarasi. S, Premkumar. T, Gopikrishnan M, Nagabhishek. N, Devaki T. Geraniol attenuates 4nqo induced tongue carcinogenesis through downregulating the activation of NF-κB in rats. Mol Cell Biochem. 2017. (PMID: 28397014)
22. Seung Jun Lee, Jayaraman Theerthagiri, Palaniyandy Nithyadharseni, Prabhakarn Arunachalam, Dhandapani, A Madan Kumar, Jagannathan Madhavan, Vikas Mittal, Myong Yong Choi. Heteroatom-doped graphene-based materials for sustainable energy applications: A review. Renewable and Sustainable Energy Reviews 143 (2021) 11084. (Impact Factor-16.799).
23. Antony Samrot, Lavanya Agnes Angalene, A. Madan Kumar and SureshKumar. Purification, characterization and exploitation of Azadirachta indica gum for the production of drug loaded nanocarrier. Materials Research Express, 7 (2020) 055007. (Impact Factor-1.41).
24. Gayathri Karanam, A. Madan Kumar. Reactive oxygen species generation and mitochondrial dysfunction for the initiation of apoptotic cell death in human hepatocellular carcinoma HepG2 cells by a cyclic dipeptide Cyclo(-Pro-Tyr). April (2020). Molecular Biology Reports (Impact Factor-2.107).
25. Durairaj G.K, Chezhiyan S, A. Madan Kumar, Nattamai S.P, Suvankar G, Priyadip D, Mani Ganeshpandian. Encapsulation of Ru(n6-p-cymene) complex of the antibacterial drug trimethoprim into a polydiacetylene phospholipid assembly to enhance its in vitro anticancer and antibacterial activities. New J. Chem., (2020) 44, 20047-20059 (Impact Factor – 3.591).
26. Chennakrishnan, F. R. Fronczek, A. Madan kumar and R. Prabhakaran. Synthesis and spectral characterizations of water soluble Cu(II) complexes containingNheterocyclic chelates: cell-proliferation, antioxidant and nucleic acid/serum albumin interactions. New J. Chem., (2020), DOI: 10.1039/C9NJ04136B. (Impact Factor-3.591).
27. Gayathri Karanam, A. Madan Kumar. Combination of ZnO Nanoparticle with Marine Sponge Derived Dipeptide for Enhanced Anticancer Efficacy in Liver Cancer Cells and their Toxicity Evaluation on Embryonic Zebrafish. January 2020. Current Analytical Chemistry (Impact Factor-1.242).
28. 10.Elamathi, R. J. Butcher, A. Mohankumar, P. Sundararaj, A. Madankumar, P. Kalaivanie and R. Prabhakaran. A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging. Inorg. Chem. Front., 2019, 6, 3237 (Impact Factor-5.165).
29. 11.Antony V.Samrot, Lavanya AgnesAngalene, Roshini, Stefi, A. MadanKumar, SureshKumar. Purification, characterization and utilization of polysaccharide of Araucaria heterophylla gum for the synthesis of curcumin loaded nanocarrier. International Journal of Biological Macromolecules. Volume 140, 2019, Pages 393-400 (Impact Factor-4.784).
30. Saleem S, Kannan RR. Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery. Nanoscale Research Letters. 2021 Dec;16(1):1-4. https://doi.org/10.1186/s11671-021-03592-1 IF: 4.46
31. Sundarraj S, Sujitha MV, Alphonse CR, Kalaiarasan R, Kannan RR. Bisphenol-A alters hematopoiesis through EGFR/ERK signaling to induce myeloblastic condition in zebrafish model. Science of The Total Environment. 2021 Sep 15; 787:147530. https://doi.org/10.1016/j.scitotenv.2021.147530 IF: 10.7
32. Mary TR, Kannan RR, Iniyan AM, Vincent SG. Statistical optimization of fermentation media for beta lactamase inhibitor kalafungin production from marine Streptomyces sp. SBRK1. Journal of Applied Biology and Biotechnology. 2021 Apr 20;9(3):8-7. http://dx.doi.org/10.7324/JABB.2021.9312 IF: 0.85
33. Kesh S, Kannan RR. Neuroprotective Effect of Tephrosia purpurea Against Mitochondrial Dysfunction by Regulation of the Caspase3/9 and Pink1/Parkin Complexes. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2021 Apr 1;11(2):137. https://www.ijnpnd.com/text.asp?2021/11/2/137/314375 IF: 0.62
34. Mary TR, Kannan RR, Iniyan AM, Ramachandran D, Vincent SG. Cell wall distraction and biofilm inhibition of marine Streptomyces derived angucycline in methicillin resistant Staphylococcus aureus. Microbial Pathogenesis. 2021 Jan 1; 150:104712. https://doi.org/10.1016/j.micpath.2020.104712 IF: 3.738
35. Kesh S, Kannan RR, Sivaji K, Balakrishnan A. Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson’s disease model. Neuroscience Letters. 2021 Jan 1; 740:135426. https://doi.org/10.1016/j.neulet.2020.135426 IF: 2.81
36. Kesh S, Kannan RR, Balakrishnan A. Naringenin alleviates 6-hydroxydopamine induced Parkinsonism in SHSY5Y cells and zebrafish model. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2021 Jan 1; 239:108893. https://doi.org/10.1016/j.cbpc.2020.108893 IF: 3.22
37. Nathan J, Kannan RR. Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research. Heliyon. 2020 Dec 1;6(12): e05662. https://doi.org/10.1016/j.heliyon.2020.e05662 IF:
38. Pitchai A, Kannan RR, Mani R, Nagarajan N. Molecular interaction of human acetylcholinesterase with trans-tephrostachin and derivatives for Alzheimer's disease. Heliyon. 2020 Sep 1;6(9): e04930. https://doi.org/10.1016/j.heliyon.2020.e04930 IF: 2.85
39. Persia Jothy T, Kannan RR, Subramoniam T. Lipid and carotenoid metabolism in the developing embryos of the intertidal anomuran crab, Emerita asiatica (Milne Edwards). Invertebrate Reproduction & Development. 2019 Jul 3;63(3):135-45. https://doi.org/10.1080/07924259.2019.1608325 IF: 1.68
40. Saleem S, Kannan RR. Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery. Cell death discovery. 2018 Oct 3;4(1):1-3. https://doi.org/10.1038/s41420-018-0109-7 IF: 4.53
41. Pitchai A, Nagarajan N, Vincent SG, Kannan RR. Zebrafish bio-assay guided isolation of human acetylcholinesterase inhibitory trans-tephrostachin from Tephrosia purpurea (L.) Pers. Neuroscience Letters. 2018 Nov 20; 687:268-75. https://doi.org/10.1016/j.neulet.2018.09.058 IF: 2.81
42. Nagarajan N, Chellam J, Kannan RR. Exploring the functional impact of mutational drift in LRRK2 gene and identification of specific inhibitors for the treatment of Parkinson disease. Journal of Cellular Biochemistry. 2018 Jun;119(6):4878-89. https://doi.org/10.1002/jcb.26703 IF: 4.429
43. Nagasundaram N, Wilson Alphonse CR, Samuel Gnana PV, Kannan RR. Molecular dynamics validation of crizotinib resistance to ALK mutations (L1196M and G1269A) and identification of specific inhibitors. Journal of Cellular Biochemistry. 2017 Oct;118(10):3462-71. https://doi.org/10.1002/jcb.26004 IF: 4.429
44. Carlton Ranjith W.A.; Rajesh Kannan, R.; Nagarajan, N. PITRM1 Interaction Studies with Amyloidogenic Nonapeptide Mutants of Familial Alzheimer’s Disease. J. Biomol. Struct. Dyn. 2022, 1–12, doi:10.1080/07391102.2022.2092554.(IF 5.23)
45. Carlton Ranjith W. A.; Rajaretinam, R.K. Habituation and Behavioural Response of Confinement-Induced Anxiety Conditions in a Zebrafish Model. Appl. Biosci. 2022, Vol. 1, Pages 315-323 2022, 1, 315–323, doi:10.3390/APPLBIOSCI1030020.
46. Sundarraj, S.; Sujitha, M. V; Carlton Ranjith W. A, Kalaiarasan, R.; Kannan, R.R. Bisphenol-A Alters Hematopoiesis through {EGFR}/{ERK} Signaling to Induce Myeloblastic Condition in Zebrafish Model. Sci. Total Environ. 2021, 787, 147530, doi:10.1016/j.scitotenv.2021.147530. (IF 10.75).
47. Sundarraj, S.; Muneeswaran, S.; Carlton Ranjith W. A.; Sujitha, M. V.; Soundharapandiyan, N.; Rajendran, V.; Kannan, R.R. The UV-B Protective Effect of a SiO2 Doped TiO2 Thin Film Regulates Pitx3 and Sparc Expression during Embryonic Development of Zebrafish. Environ. Sci. Nano 2022, 9, 3809–3820, doi:10.1039/d2en00236a. (IF 9.47).
48. Haridevamuthu, B.; Manjunathan, T.; Carlton Ranjith W. A.; Kumar, R.S.; Thanigaivel, S.; Kishore, S.C.; Sundaram, V.; Gopinath, P.; Arockiaraj, J.; Bellucci, S. Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro. Molecules 2023, 28, 1856, doi:10.3390/molecules28041856. (IF 4.92).
49. Kundu, B.K.; Pragti; Carlton Ranjith W. A.; Shankar, U.; Kannan, R.R.; Mobin, S.M.; Bandyopadhyay, A.; Mukhopadhyay, S. Cancer-Targeted Chitosan–Biotin-Conjugated Mesoporous Silica Nanoparticles as Carriers of Zinc Complexes to Achieve Enhanced Chemotherapy In Vitro and In Vivo. ACS Appl. Bio Mater. 2022, 5, 190–204, doi:10.1021/acsabm.1c01041. (IF 3.95)
50. Haridevamuthu, B.; Manjunathan, T.; Guru, A Carlton Ranjith W. A.; Boopathi, S.; Murugan, R.; Gatasheh, M.K.; Hatamleh, A.A.; Juliet, A.; Gopinath, P.; et al. Amelioration of Acrylamide Induced Neurotoxicity by Benzo[b]Thiophene Analogs via Glutathione Redox Dynamics in Zebrafish Larvae. Brain Res. 2022, 1788, 147941, doi:10.1016/j.brainres.2022.147941. (IF 3.61)
51. Pushpabai, R.R.; Carlton Ranjith W. A.; Mani, R.; Apte, D.A.; Franklin, J.B. Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus Bayani as Determined from Transcriptomic and Proteomic Analyses. Mar. Drugs 2021, 19, 202, doi:10.3390/md19040202. (IF 6.08)
52. Sivaji, K.; Kannan, R.R.; Nandhagopal, S.; Carlton Ranjith W. A.; Saleem, S. Exogenous Human Beta Amyloid Peptide Interferes Osteogenesis through Sox9a in Embryonic Zebrafish. Mol. Biol. Rep. 2019, 46, 4975–4984, doi:10.1007/s11033-019-04948-8. (IF 2.74)
53. Premachandran, K.; Srinivasan, T.S.; Carlton Ranjith W. A.; In Silico Approach on Sequential and Structural Variability in Oryzacystatin and Its Interaction with Cysteine Protease Enzymes of Insect. Phytochemistry 2021, 186, 112728, doi:10.1016/j.phytochem.2021.112728. (IF 4.04)
54. Jain, R.P.; Jayaseelan, B.F.; Carlton Ranjith W. A.; Mahmoud, A.H.; Mohammed, O.B.; Ahmed Almunqedhi, B.M.; Rajaian Pushpabai, R. Mass Spectrometric Identification and Denovo Sequencing of Novel Conotoxins from Vermivorous Cone Snail (Conus Inscriptus), and Preliminary Screening of Its Venom for Biological Activities in Vitro and in Vivo. Saudi J. Biol. Sci. 2021, 28, 1582–1595, doi:10.1016/j.sjbs.2020.12.032. (IF 4.05)
55. Rajesh, R.; Carlton Ranjith W. A.; Das, M.M.; Vanathi, G. Mass Spectrometry Based De-Novo Sequencing of Carpenter Bee Venom and Their In-Silico 3-D Structure Determination and Functional Analysis. Int. J. Infect. Dis. 2022, 116, S107–S108, doi:10.1016/j.ijid.2021.12.253. (IF 12.07-proceeding)
56. Nagasundaram, N.; Carlton Ranjith W. A.; Samuel Gnana, P.V.; Rajaretinam, R.K. Molecular Dynamics Validation of Crizotinib Resistance to ALK Mutations (L1196M and G1269A) and Identification of Specific Inhibitors. J. Cell. Biochem. 2017, 118, 3462–3471, doi:10.1002/jcb.26004. (IF 4.48)
57. Jabila Mary, T.R.; Kannan, R.R.; Muthamil Iniyan, A.; Carlton Ranjith W. A.; Nandhagopal, S.; Vishwakarma, V.; Prakash Vincent, S.G. β-Lactamase Inhibitory Potential of Kalafungin from Marine Streptomyces in Staphylococcus Aureus Infected Zebrafish. Microbiol. Res. 2021, 244, 126666, doi:10.1016/j.micres.2020.126666. (IF 5.07)
58. Suraiya Saleem, R Bannerjee and Kannan RR Chrysin-Loaded Chitosan Nanoparticle-Mediated Neuroprotection in Aβ1–42-Induced Neurodegenerative Conditions in Zebrafish (2022) https://doi.org/10.1021/acschemneuro.2c00240 IF. 5.7
59. Soundhara pandiyan N, Thanumalaya perumal S, Kannan RR. Real‐time imaging and developmental biochemistry analysis during embryogenesis of Caridina pseudogracilirostris. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 2021 Nov 15. https://doi.org/10.1002/jez.2556 IF: 2.039
60. Saleem S, Kannan RR. Journal of Neurology and Brain Research, 2020. DOI: 10.47755/J Neuro Brain Res.2020.1.002
61. Nathan JR, Kurmi B, Soundharapandian N, Kannan RR. In vivo molecular validation of VEGF inhibitor extracted from marine Actinomycetes in zebrafish embryos. 2020. http://nopr.niscair.res.in/handle/123456789/54941 IF: 0.414
62. Sivaji K, Kannan RR. Polysorbate 80 coated gold nanoparticle as a drug carrier for brain targeting in zebrafish model. Journal of Cluster Science. 2019 Jul;30(4):897-906. https://doi.org/10.1007/s10876-019-01548-1 IF: 2.78
63. Pitchai A, Kannan RR, Freeman JL. Zebrafish as an emerging model for bioassay-guided natural product drug discovery for neurological disorders. Medicines. 2019 Jun;6(2):61. https://doi.org/10.3390/medicines6020061 IF: 1.889•
64. Rajesh RP, Franklin JB, Badsha I, Arjun P, Jain RP, Vignesh MS, Kannan RR. proteome based de novo sequencing of novel conotoxins from marine molluscivorous cone snail Conus amadis and neurological activities of its natural venom in zebrafish model. Protein and Peptide Letters. 2019 Nov 1;26(11):819-33. https://doi.org/10.2174/0929866526666190614144006 IF: 1.89
65. Iniyan AM, Sudarman E, Wink J, Kannan RR, Vincent SG. Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19. The Journal of Antibiotics. 2019 Feb;72(2):99-105. https://doi.org/10.1038/s41429-018-0115-2 IF: 1.730
66. Iniyan AM, Wink J, Landwehr W, Ramprasad EV, Sasikala C, Ramana CV, Schumann P, Spröer C, Bunk B, Joseph FJ, Joshua SA… Streptomyces marianii sp. nov., a novel marine actinomycete from southern coast of India. The Journal of Antibiotics. 2021 Jan;74(1):59-69. https://doi.org/10.1038/s41429-020-0360-z IF: 1.730
67. García-Reyes S, Yáñez-Ocampo G, Wong-Villarreal A, Rajaretinam RK, Thavasimuthu C, Patiño R, Ortiz-Hernández ML. Partial characterization of a biosurfactant extracted from Pseudomonas sp. B0406 that enhances the solubility of pesticides. Environmental technology. 2018 Oct 18;39(20):2622-31. https://doi.org/10.1080/21622515.2017.1363295 IF: 8.49
68. Iniyan AM, Kannan RR, Joseph FJ, Mary TR, Rajasekar M, Sumy PC, Rabel AM, Ramachandran D, Vincent SG. In vivo safety evaluation of antibacterial silver chloride nanoparticles from Streptomyces exfoliatus ICN25 in zebrafish embryos. Microbial pathogenesis. 2017 Nov 1; 112:76-82. https://doi.org/10.1016/j.micpath.2017.07.054 IF: 3.738
69. Iniyan AM, Kannan RR, Vincent SG. Characterization of culturable actinomycetes associated with halophytic rhizosphere as potential source of antibiotics. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2017 Mar;87(1):233-42. https://doi.org/10.1007/s40011-015-0601-2 IF: 4.858
70. Christyraj, Jackson Durairaj Selvan, Ananthaselvam Azhagesan, Mijithra Ganesan, Karthikeyan Subbiah Nadar Chelladurai, Vennila Devi Paulraj, and Johnson Retnaraj Samuel Selvan Christyraj. "Understanding the Role of the Clitellum in the Regeneration Events of the Earthworm Eudrilus eugeniae." Cells Tissues Organs 208, no. 3-4 (2019): 134-141.
71. Subbiahanadar Chelladurai, Karthikeyan, Jackson Durairaj Selvan Christyraj, Ananthaselvam Azhagesan, Vennila Devi Paulraj, Muralidharan Jothimani, Beryl Vedha Yesudhason, Niranjan Chellathurai Vasantha et al. "Exploring the effect of UV-C radiation on earthworm and understanding its genomic integrity in the context of H2AX expression." Scientific Reports 10, no. 1 (2020): 21005.
72. Chelladurai, Karthikeyan Subbiahanadar, Jackson Durairaj Selvan Christyraj, Kamarajan Rajagopalan, Beryl Vedha Yesudhason, Saravanakumar Venkatachalam, Manikandan Mohan, Niranjan Chellathurai Vasantha, and Johnson Retnaraj Samuel Selvan Christyraj. "Alternative to FBS in animal cell culture-An overview and future perspective." Heliyon 7, no. 8 (2021): e07686.
73. Jebaranjitham, J. Nimita, Jackson Durairaj Selvan Christyraj, Adhimoorthy Prasannan, Kamarajan Rajagopalan, Karthikeyan Subbiahanadar Chelladurai, and Jemima Kamalapriya John Samuel Gnanaraja. "Current scenario of solid waste management techniques and challenges in Covid-19-A review." Heliyon (2022): e09855.
74. Paul, Sayan, Subburathinam Balakrishnan, Arun Arumugaperumal, Saranya Lathakumari, Sandhya Soman Syamala, Vijithkumar Vijayan, Selvan Christyraj Jackson Durairaj, Vaithilingaraja Arumugaswami, and Sudhakar Sivasubramaniam. "Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae." Functional & Integrative Genomics 22, no. 4 (2022): 1-32.
75. Rajagopalan, Kamarajan, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, Jemima Kamalapriya John Samuel Gnanaraja, and Johnson Retnaraj Samuel Selvan Christyraj. "Comparative analysis of the survival and regeneration potential of juvenile and matured earthworm, Eudrilus eugeniae, upon in vivo and in vitro maintenance." In Vitro Cellular & Developmental Biology-Animal 58, no. 7 (2022): 587-598.
76. M. Rajasekar, Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus Bayani as Determined from Transcriptomic and Proteomic Analyses, Mar. Drugs, 2021, 19, 202.
77. M. Rajasekar, Recent Trends in Rhodamine derivatives as fluorescent probes for biomaterial applications, J. Mol. Struct., 2021, 1235 130232.
78. M. Rajasekar, Recent development in fluorescein derivatives, J. Mol. Struct., 2021, 1224, 129085
79. M. Rajasekar, Synthesis, and characterization of hesperetin derivatives and toxicity level of the zebrafish model, Heliyon, 2021, 7, e06066
80. M. Rajasekar, Molecular interaction of human acetylcholinesterase with trans-tephrostachin and derivatives for Alzheimer's disease, Heliyon, 2020, 6, e04930
81. Nandhagopal S, Iniyan AM, Kannan RR, Vincent SG. In vivo evaluation of anti-MRSA compound from Streptomyces collinus ICN1 in zebrafish embryos, 2017. http://nopr.niscair.res.in/handle/123456789/42005.
Contact Us
Dr. T. Sasipraba,
Vice Chancellor,
Centre for Nanoscience & Nanotechnology,
Sathyabama Institute of Science and Technology
(Deemed to be University),
Jeppiaar Nagar, Rajiv Gandhi Road, Chennai-600119,
Tamilnadu, India
Phone : +91-44-2450 3065
Fax : +91-44-2450 3814
Email: [email protected]
